FREE SHIPPING on USA Orders $50+ / International Orders $75+

FREE SHIPPING on USA Orders $50+ / International Orders $75+

Wishlist  0 items - $0.00

Your Cart is Empty

Skincare Ingredients Not to Mix

Skincare Ingredients Not to Mix

If you’re into skincare, you likely have a vanity full of amazing actives, serums, and moisturizers meant to hydrate, smooth, and slough away stubborn spots or dead cells. And it’s true that a comprehensive routine is necessary if you want to see real results.

But not all ingredients play nice with one another - and while some go together like PB&J, other mixtures should be avoided at all costs. Here, we’ll break down the do’s and don’t of mixing skincare ingredients so you’ll always get the perfect glow, not a face full of oh no!

First Thing’s First: Active Ingredients

Generally speaking, when we talk about skincare products that react with one another (either positively or negatively) that reaction usually has to do with the active ingredients in the product.

Active skincare ingredients are the ingredients that actually work to address the problem that the product is meant to target. If you’re getting a serum to treat acne, for example, the active ingredient could be glycolic acid. If you want to fade dark spots, our favorite active for daily use is vitamin C.

And they’re proven to work: generally, active ingredients have been proven effective in a lab, so you won’t be dealing with snake oil. Active categories include:

  • Signs of aging: SPF-boosting ingredients (e.g. zinc oxide, titanium dioxide, avobenzone, oxybenzone), vitamin C, vitamin E.
  • Dryness: Hyaluronic acid, vitamin E.
  • Pigmentation issues: Kojic acid, AHAs, BHA, vitamin C.
  • Acne: Salicylic acid, benzoyl peroxide, glycolic acid, azelaic acid.
  • Rosacea: Various antibiotics, azelaic acid, sulfur.
  • Psoriasis: Steroids, vitamin D, glycolic acid, urea, lactic acid, anthralin, tacrolimus, pimecrolimus.
  • Eczema: Steroids, tacrolimus, pimecrolimus.

Skincare Ingredients That Work Well Together

Vitamin C + Vitamin E

Vitamin C and vitamin E are two antioxidant powerhouses that go together flawlessly - and you won’t have to worry about getting too much of a good thing.

Each vitamin combats different types of UV damage, which means that the combination - especially if you add some real SPF to the mix - will give you ultra-comprehensive sun protection. Additionally, using both will give you double the antioxidant protection to fight free radical damage. In fact, one study found that applying the combination every day can reduce the effects of sun damage - aka dark spots and wrinkles - on your skin by up to 4 times!

Now, let’s address one of the most common concerns here - can’t loading up on double the goodies actually cause skin irritation?

The short answer? No! (yay). Neither product is recommended for particularly sensitive or reactive skin (and vitamin E is not great for oily skin either) but the reality is that we’re not dealing with acids or anything harmful. Instead, we’re talking about regenerative, restorative antioxidants, so you shouldn’t worry about the combination causing any kind of harm.

Where to find them:

If you’re following a comprehensive Eight Saints routine, you’re already using these two vitamins (woo hoo!). But just in case you’re not sure what to use (or if you want to double-check that you’re making the most of this powerful duo), you can find:

  • Vitamin C in:
    • Down to Earth Gel Cleanser, a gentle clay-based cleanser that’s perfect for normal, oily, and combination skin.
    • Cloud Whip Face Cream, an everyday vitamin C face cream that will brighten skin, fade discoloration, and repair acne scars.


Cloud Whip Vitamin C Face Cream



Daydreamer Natural Face Moisturizer

Sunscreen + Antioxidants

Roughly 80-90% of facial skin aging is caused by sun damage, which is why sunscreen on its own is such an important part of any skincare routine. A run-of-the-mill sunscreen primarily protects against UVB rays, which cause the reddening that is typically associated with sunburn and, in the long run, skin cancer.


A broad-spectrum sunscreen will protect against both UVB and UVA rays, the rays that can reach deeper layers of the skin and damage collagen and elastin. An SPF 30, in particular, will protect against 97% of these harmful rays (not too shabby).

That said, sunscreen on its own can only protect against about 55% of free radicals caused by UV exposure. Free radicals are unstable molecules (caused by sun damage, environmental pollutants, etc) that steal electrons from within cells to try to stabilize themselves, disrupting the cell membrane, setting the mitochondria on a self-destructive path, and creating errors in the DNA within the nucleus - yikes!

If this process goes unchecked, you’ll have a face full of unstable cells that are destroying their neighbors and stealing from each other. This wreaks havoc on the skin, leading to:

  • Premature and accelerated aging of the skin, including wrinkles and loss of elasticity
  • Hyperpigmentation
  • Inflammatory conditions, such as acne and rosacea
  • Skin cancer

That’s why you should add antioxidants to your SPF - they can help and reduce these free radicals by up to 78%. Plus, many alsoblock harmful UV rays, making SPF and antioxidants the ultimate sun protection duo.

Where to find them:

Our Chase the Sun SPF 30 Face Moisturizer contains a blend of mineral and clean chemical sunscreen actives to provide invisible, complete protection from harmful UVA/UVB rays - along with hyaluronic Acid, squalane, and aloe vera.


Chase the Sun SPF 30 Face Moisturizer

Green Tea + Caffeine


Green tea has anti-inflammatory properties, antioxidant effects, and protective benefits. It can help with:

  • Puffy eyes: You can put green tea bags on your eyes to reduce puffiness; it works because compounds in green tea reduce irritation and redness while speeding along the decongestion and de-stressing of your system.
  • Blemish control: The catechins in green tea have antimicrobial properties. These can destroy stubborn acne-causing bacteria on the skin.
  • Sunburn repair: Green tea activates EGCG, a super compound believed to reduce the metabolic changes in the skin that lead to skin cancer and wrinkles (not to mention help with sunburn) - yay!

Some research suggests that caffeine enhances the antioxidant effects of green tea polyphenols and that both ingredients together may help prevent free radical production and UVB-induced skin cancer.

Where to find them:

Our Pep Rally Face Serum is loaded with organic green tea extract, hyaluronic acid, and vitamin C - which means you can kiss those burns and fine lines goodbye.



Pep Rally Face Serum


Glycolic Acid + Vitamin C

Although this combination may not be suitable for all skin types, glycolic acid and vitamin C make a powerful pairing. They both boost collagen levels in the skin, and it appears that their effects may be additive.

Additionally, vitamin C and glycolic acid are both effective at inhibiting tyrosinase and decreasing melanin production. As a result, when used together, they demonstrated an ability to significantly improve hyperpigmentation and dark spots, as well as reduce pore size and improve skin texture.

Where to find them:

Vitamin C is a key ingredient in our Down to Earth Gel Cleanser, Cloud Whip Face Cream, and Pep Rally Face Serum.

You'll benefit from the revitalizing power of glycolic acid when you use our Soulmate Brightening Treatment and Bright Side Cream Cleanser.


Soulmate Brightening Treatment

Skincare Products You Shouldn't Mix

Retinol + AHAs/BHAs

Retinoids (the umbrella term for retinol creams) are ultra-potent skincare ingredients that come in a lot of forms. There’s:

  • Retinoic acid: This is the “magic ingredient” that you’ll find in a lot of prescription anti-aging products.
  • Retinol: This vitamin A derivative is the non-prescription alternative to retinoic acid (and it’ll be converted to retinoic acid at a cellular level). It biochemically does the same thing as the prescription stuff - it’ll just take a little bit longer for you to start seeing results.
  • Pro-retinols: This includes ingredients like retinyl palmitate, retinyl acetate, and retinyl linoleate. These are the gentlest of the bunch.

Retinoids are not exfoliants. Any peeling they cause is a side effect of the irritation - not an intended effect.


Instead, retinols primarily work by affecting gene expression and causing enhanced collagen production, skin smoothing, and an evening of pigmentation.

AHAs and BHAs, on the other hand, are chemicals that work to “unglue” the bonds that hold dead skin to the face, thereby helping to gently exfoliate the skin. Over time, they can help:

  • Improve look and feel of the skin
  • Smooth texture and decrease imperfections
  • Hydrate
  • Diminish fine lines and wrinkles

What's the problem? Why are these skincare ingredients not to mix together Retinol is extremely unstable and using it with acids is hard on the skin. Together, they may cause dryness, sensitivity, and irritation - particularly if you already have sensitive skin or use strong concentrations.

Benzoyl Peroxide + Retinol/Tretinoin

Benzoyl peroxide is an effective acne-fighting ingredient that can reduce the amount of acne-causing bacteria on the skin. But when retinol products are combined with benzoyl peroxide products, their effects cancel each other out.

These are skincare products you shouldn't mix because benzoyl peroxide and retinols can deactivate each other on the skin. So, if you have to use both, you should do so at different times so the products don’t interfere with one another.

Oil-Based + Water-Based Products

This one isn’t as much a statement about what notto do as it is a guideline about how to mix these ingredients.

Oil and water don’t mix - when it comes to skincare, this means that oil-based products leave a film on the skin that water-based products won’t be able to penetrate. If you follow an oil-based cleanser with a water-based vitamin C serum, for example, you won’t see your dark spots start to lighten. And you might think a faulty vitamin C product is to blame.

Of course, this is not a hard-and-fast rule against all oil and water mixtures. Botanical face oils can be effectively used on top of water-based products at the end of your skincare routine to seal everything in. This can work as a shield for the skin, keeping vitamins and nutrients in, giving actives an opportunity to sink in more deeply, and preventing trans-epidermal water loss.

Niacinamide + Vitamin C

Niacinamide cancels out all of the good properties of vitamin C and turns it into a substance that causes redness. Acne breakouts can also be triggered when the products are applied directly on top of one another.

If you’re going to use both, space application out by at least 10 minutes between each product to avoid any irritation.

And remember - always pay attention to your skin! If you notice any redness, irritation, itching, or other symptoms, re-evaluate your routine and get to the bottom of it before the problem gets worse.